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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473 Species: Mus musculus RGD Object: Gene Symbol: Nqo1 Name: NAD(P)H dehydrogenase, quinone 1

Acc ID: CHEBI:50692 Term: mifepristone Definition: A 3-oxo steroid that has formula C29H35NO2. CasRN: 84371-65-3 Chemical ID: MESH:D015735

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:735868	6480464	CTD	Mifepristone results in decreased expression of NQO1 mRNA	PMID:17584828
multiple interactions	ISO	RGD:2503	6480464	CTD	Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]]	PMID:17690134
multiple interactions	ISO	RGD:2503	6480464	CTD	Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [benz(a)anthracene results in increased activity of NQO1 protein]]	PMID:7587946