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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621400
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i3
Name: nuclear receptor subfamily 1, group I, member 3
Acc ID: CHEBI:50648
Term: 9-cis-retinoic acid
Definition: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Chemical ID: MESH:C103303
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i3multiple interactionsISONR1I3 (Homo sapiens)6480464CTD1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; [1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with Alitretinoin] promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin binds to and results in increased activity of NR1I3 protein alternative form; Alitretinoin promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]]; Alitretinoin promotes the reaction [[NR1I3 protein binds to RXRA protein] which binds to NCOA1 protein]; Alitretinoin promotes the reaction [[RXRA protein binds to NR1I3 protein] which binds to CYP3A4 promoter]PMID:17223708 PMID:19686701 PMID:31312845
Nr1i3multiple interactionsISONr1i3 (Mus musculus)6480464CTDAlitretinoin results in increased activity of [RXRA protein binds to NR1I3 protein]PMID:19686701
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