GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Rara | increases expression | EXP | | 6480464 | CTD | Alitretinoin results in increased expression of RARA protein | PMID:16043492 | Rara | multiple interactions | EXP | | 6480464 | CTD | [Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]; CAMK4 protein promotes the reaction [Alitretinoin results in increased activity of RARA protein]; Dizocilpine Maleate inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; KN 62 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; Okadaic Acid promotes the reaction [Alitretinoin results in increased activity of RARA protein]; STO 609 inhibits the reaction [[Bicuculline co-treated with 4-Aminopyridine] promotes the reaction [Alitretinoin results in increased activity of RARA protein]]; trichostatin A promotes the reaction [Alitretinoin results in increased activity of RARA protein] | PMID:15773917 | Rara | decreases expression | ISO | RARA (Homo sapiens) | 6480464 | CTD | Alitretinoin results in decreased expression of RARA protein | PMID:15375546 | Rara | increases expression | ISO | Rara (Mus musculus) | 6480464 | CTD | Alitretinoin results in increased expression of RARA mRNA | PMID:8892963 | Rara | increases expression | ISO | RARA (Homo sapiens) | 6480464 | CTD | Alitretinoin results in increased expression of RARA mRNA | PMID:11139446 PMID:17034753 PMID:36805303 | Rara | multiple interactions | ISO | RARA (Homo sapiens) | 6480464 | CTD | Alitretinoin binds to and results in increased activity of RARA protein; Alitretinoin promotes the reaction [RARA protein binds to PRAME protein]; RARA protein promotes the reaction [Alitretinoin results in increased expression of ABCC6 mRNA] | PMID:16179254 PMID:17045963 PMID:18180267 | | ||||||||||||||||||||||
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