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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2274
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp1
Name: caspase 1
Acc ID: CHEBI:50594
Term: carbon nanotube
Definition: A molecule consisting of a graphene cylinder or two or more concentric graphene cylinders.
Chemical ID: MESH:D037742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp1increases expressionISOCasp1 (Mus musculus)6480464CTDNanotubes, Carbon analog results in increased expression of CASP1 mRNA; Nanotubes, Carbon results in increased expression of CASP1 mRNA; Nanotubes, Carbon results in increased expression of CASP1 proteinPMID:25554681 PMID:26091108
Casp1increases secretionISOCASP1 (Homo sapiens)6480464CTDNanotubes, Carbon results in increased secretion of CASP1 protein modified formPMID:24760326
Casp1multiple interactionsISOCasp1 (Mus musculus)6480464CTDAntigens, Dermatophagoides inhibits the reaction [Nanotubes, Carbon results in increased expression of CASP1 protein]PMID:26091108
Casp1multiple interactionsISOCASP1 (Homo sapiens)6480464CTD[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA; [IL13 protein co-treated with IL4 protein co-treated with Nanotubes, Carbon] inhibits the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] affects the expression of CASP1 protein]; [IL4 protein co-treated with IL13 protein] inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]]; IL4 protein inhibits the reaction [Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]]; Nanotubes, Carbon promotes the reaction [[Calcitriol co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides co-treated with Nanotubes, Carbon] affects the expression of CASP1 mRNA]; Y 27632 inhibits the reaction [Nanotubes, Carbon results in increased secretion of CASP1 protein modified form]PMID:24760326 PMID:26091108
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