GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | decreases expression | EXP | | 6480464 | CTD | Hemin results in decreased expression of NFE2L2 protein | PMID:25824035 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Hemin results in increased expression of NFE2L2 protein | PMID:25824035 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [[[Oxygen deficiency co-treated with Blood Glucose deficiency] co-treated with [Oxygen co-treated with Blood Glucose]] co-treated with Hemin] affects the localization of NFE2L2 protein; Hemin promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in decreased expression of NFE2L2 protein]; tin protoporphyrin IX inhibits the reaction [Hemin results in increased expression of NFE2L2 protein]; zinc protoporphyrin inhibits the reaction [Hemin results in increased expression of NFE2L2 protein] | PMID:23272707 PMID:25824035 PMID:26747958 | Nfe2l2 | affects localization | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Hemin affects the localization of NFE2L2 protein | PMID:16959797 PMID:21525764 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Hemin results in increased expression of NFE2L2 protein | PMID:31054940 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | Hemin results in increased expression of NFE2L2 protein | PMID:27777014 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | [Antineoplastic Agents binds to and results in decreased activity of NFE2L2 protein] inhibits the reaction [Hemin results in increased expression of SESN2 protein]; [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Hemin] results in increased expression of and affects the localization of NFE2L2 protein; diacetyldichlorofluorescein inhibits the reaction [Hemin affects the localization of NFE2L2 protein]; Hemin promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Hemin results in increased expression of and affects the localization of NFE2L2 protein; SESN2 protein inhibits the reaction [Hemin results in increased expression of NFE2L2 protein] | PMID:16959797 PMID:21464371 PMID:31054940 PMID:33434570 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Mus musculus) | 6480464 | CTD | NFE2L2 gene mutant form inhibits the reaction [Hemin results in increased expression of CYP2A5 mRNA]; NFE2L2 protein affects the reaction [Hemin results in increased expression of HMOX1 mRNA] | PMID:10473555 PMID:22859313 | | ||||||||||||||||||||||
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