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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:50182
Term: 3,3'-diindolylmethane
Definition: An indole that has formula C17H14N2.
Chemical ID: MESH:C016392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2increases expressionEXP 6480464CTD3,3'-diindolylmethane results in increased expression of CYP1A2 proteinPMID:8384853
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTD3,3'-diindolylmethane results in decreased activity of CYP1A2 proteinPMID:19770484
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTD3,3'-diindolylmethane results in increased expression of CYP1A2 mRNA; 3,3'-diindolylmethane results in increased expression of CYP1A2 proteinPMID:15672752 PMID:19770484
Cyp1a2increases oxidationISOCYP1A2 (Homo sapiens)6480464CTDCYP1A2 protein results in increased oxidation of 3,3'-diindolylmethanePMID:16544949
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTD[3,3'-diindolylmethane results in increased expression of CYP1A2 mRNA] which results in increased abundance of aflatoxin B1-DNA adduct; Quercetin inhibits the reaction [CYP1A2 protein results in increased oxidation of 3,3'-diindolylmethane]; resveratrol inhibits the reaction [CYP1A2 protein results in increased oxidation of 3,3'-diindolylmethane]PMID:16544949 PMID:19770484
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