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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631 Species: Homo sapiens RGD Object: Gene Symbol: CYP11A1 Name: cytochrome P450, family 11, subfamily A, polypeptide 1

Acc ID: CHEBI:5014 Term: fenvalerate Definition: A carboxylic ester obtained by formal condensation between 2-(4-chlorophenyl)-3-methylbutyric acid and cyano(3-phenoxyphenyl)methanol. CasRN: 51630-58-1 Chemical ID: MESH:C017690

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:69325	6480464	CTD	fenvalerate results in increased expression of CYP11A1 mRNA	PMID:16001830
decreases activity	ISO	RGD:735632	6480464	CTD	fenvalerate results in decreased activity of CYP11A1 protein	PMID:18053657
decreases expression	ISO	RGD:735632	6480464	CTD	fenvalerate results in decreased expression of CYP11A1 protein fenvalerate results in decreased expression of CYP11A1 mRNA	PMID:18053657
decreases expression	ISO	RGD:69325	6480464	CTD	fenvalerate results in decreased expression of CYP11A1 mRNA fenvalerate results in decreased expression of CYP11A1 protein	PMID:15907653
decreases expression	ISO	RGD:69325	6480464	CTD	fenvalerate results in decreased expression of CYP11A1 mRNA	PMID:15907653 PMID:19892000
decreases expression	ISO	RGD:735632	6480464	CTD	fenvalerate results in decreased expression of CYP11A1 protein fenvalerate results in decreased expression of CYP11A1 mRNA	PMID:18053657 PMID:19683566
decreases expression	ISO	RGD:735632	6480464	CTD	fenvalerate results in decreased expression of CYP11A1 protein fenvalerate results in decreased expression of CYP11A1 mRNA	PMID:18053657 PMID:19683566 PMID:20063364