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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2332
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cftr
Name: CF transmembrane conductance regulator
Acc ID: CHEBI:50138
Term: lonidamine
Definition: A member of the class of indazoles that is 1H-indazole that is substituted at positions 1 and 3 by 2,4-dichlorobenzyl and carboxy groups, respectively.
Chemical ID: MESH:C016371
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cftrmultiple interactionsEXP 6480464CTDlonidamine inhibits the reaction [CFTR protein promotes the reaction [AQP9 protein affects the transport of Water]]PMID:12606488
Cftrdecreases activityISOCFTR (Homo sapiens)6480464CTDlonidamine results in decreased activity of CFTR proteinPMID:15634668
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