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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115 Species: Homo sapiens RGD Object: Gene Symbol: CDKN1B Name: cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Acc ID: CHEBI:50131 Term: 5-aza-2'-deoxycytidine Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4. CasRN: 2353-33-5 Chemical ID: MESH:C014347

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	[decitabine affects the expression of DNMT3B protein] which affects the expression of CDKN1B mRNA	PMID:18544619
multiple interactions	EXP		6480464	CTD	[decitabine co-treated with trichostatin A] results in increased expression of CDKN1B mRNA	PMID:17185465
multiple interactions	EXP		6480464	CTD	[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA	PMID:18622747