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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3865 Species: Rattus norvegicus RGD Object: Gene Symbol: Timp3 Name: TIMP metallopeptidase inhibitor 3

Acc ID: CHEBI:50131 Term: 5-aza-2'-deoxycytidine Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4. CasRN: 2353-33-5 Chemical ID: MESH:C014347

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:735741	6480464	CTD	decitabine results in increased expression of TIMP3 mRNA	PMID:16367923 PMID:19215824 PMID:19417133
multiple interactions	ISO	RGD:11419	6480464	CTD	[[decitabine co-treated with trichostatin A] affects the methylation of TIMP3 promoter] which affects the expression of TIMP3 mRNA	PMID:18836996
affects methylation	ISO	RGD:735741	6480464	CTD	decitabine affects the methylation of TIMP3 promoter	PMID:17671114
increases expression	ISO	RGD:735741	6480464	CTD	decitabine results in increased expression of TIMP3 mRNA	PMID:19417133 PMID:19215824 PMID:16367923
increases expression	ISO	RGD:735741	6480464	CTD	decitabine results in increased expression of TIMP3 mRNA	PMID:19417133 PMID:16367923 PMID:19215824
multiple interactions	ISO	RGD:11419	6480464	CTD	[[decitabine co-treated with trichostatin A] affects the methylation of TIMP3 promoter] which affects the expression of TIMP3 mRNA	PMID:18836996 PMID:18836996
increases expression	ISO	RGD:735741	6480464	CTD	decitabine results in increased expression of TIMP3 mRNA	PMID:19215824 PMID:19417133 PMID:16367923