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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3732
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sod2
Name: superoxide dismutase 2
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sod2increases expressionISOSOD2 (Homo sapiens)6480464CTDDecitabine results in increased expression of SOD2 mRNA; Decitabine results in increased expression of SOD2 proteinPMID:17965603 PMID:19294695
Sod2multiple interactionsISOSOD2 (Homo sapiens)6480464CTD[trichostatin A co-treated with Decitabine] results in increased expression of SOD2 protein; Decitabine results in increased expression of and results in increased activity of SOD2 proteinPMID:17965603 PMID:19294695
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