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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802 Species: Rattus norvegicus RGD Object: Gene Symbol: Hmgb1 Name: high mobility group box 1

Acc ID: CHEBI:50131 Term: 5-aza-2'-deoxycytidine Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4. CasRN: 2353-33-5 Chemical ID: MESH:C014347

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1605729	6480464	CTD	decitabine results in decreased expression of HMGB1 mRNA	PMID:19363521
multiple interactions	ISO	RGD:1605729	6480464	CTD	TP53 protein affects the reaction [decitabine results in decreased expression of HMGB1 mRNA]	PMID:19363521