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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11485 Species: Mus musculus RGD Object: Gene Symbol: Vhl Name: von Hippel-Lindau tumor suppressor

Acc ID: CHEBI:50131 Term: 5-aza-2'-deoxycytidine Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4. CasRN: 2353-33-5 Chemical ID: MESH:C014347

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:737311	6480464	CTD	VHL protein promotes the reaction [decitabine results in increased expression of ABCG2 mRNA] VHL protein promotes the reaction [decitabine results in increased expression of ABCG2 protein]	PMID:16954373
affects expression	ISO	RGD:737311	6480464	CTD	decitabine affects the expression of VHL mRNA	PMID:16954373