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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3963 Species: Rattus norvegicus RGD Object: Gene Symbol: Vldlr Name: very low density lipoprotein receptor

Acc ID: CHEBI:50122 Term: rosiglitazone Definition: A thiazolidenedione that has formula C18H19N3O3S. CasRN: 122320-73-4 Chemical ID: MESH:C089730

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:733927	6480464	CTD	rosiglitazone inhibits the reaction [Ethanol results in decreased expression of VLDLR mRNA]	PMID:22173916
increases expression	ISO	RGD:733927	6480464	CTD	rosiglitazone results in increased expression of VLDLR mRNA rosiglitazone results in increased expression of VLDLR protein	PMID:19706614
increases expression	EXP		6480464	CTD	rosiglitazone results in increased expression of VLDLR mRNA	PMID:21515302