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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:50122 Term: rosiglitazone Definition: A thiazolidenedione that has formula C18H19N3O3S. CasRN: 122320-73-4 Chemical ID: MESH:C089730

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	rosiglitazone results in increased expression of and results in increased activity of CYP3A4 protein	PMID:12642470
decreases activity	EXP		6480464	CTD	rosiglitazone results in decreased activity of CYP3A4 protein	PMID:15860655 PMID:12642470
increases expression	EXP		6480464	CTD	rosiglitazone results in increased expression of CYP3A4 mRNA	PMID:12642470 PMID:16837568
increases expression	EXP		6480464	CTD	rosiglitazone results in increased expression of CYP3A4 mRNA	PMID:16837568 PMID:12642470
decreases activity	EXP		6480464	CTD	rosiglitazone results in decreased activity of CYP3A4 protein	PMID:12642470 PMID:15860655