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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1increases expressionEXP 6480464CTDMethylnitrosourea results in increased expression of CDK1 mRNAPMID:16525678
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDMethylnitrosourea results in decreased expression of CDK1PMID:15870882
Cdk1increases expressionISOCdk1 (Mus musculus)6480464CTDMethylnitrosourea results in increased expression of CDK1 proteinPMID:18593901
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