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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69062
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1b
Name: cyclin-dependent kinase inhibitor 1B
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1bdecreases expressionISOCDKN1B (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of CDKN1B mRNAPMID:19769630
Cdkn1bincreases expressionISOCDKN1B (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of CDKN1B gene; Arsenic Trioxide results in increased expression of CDKN1B mRNA; Arsenic Trioxide results in increased expression of CDKN1B proteinPMID:19236751 PMID:20458559 PMID:20953137 PMID:21257625 PMID:21544632 PMID:23239002 PMID:27430728 PMID:31421153 PMID:36352148
Cdkn1bmultiple interactionsISOCDKN1B (Homo sapiens)6480464CTD[Arsenic Trioxide co-treated with Curcumin] results in increased expression of CDKN1B protein; [Arsenic Trioxide co-treated with VS-5584] results in increased expression of CDKN1B mRNA; [Curcumin co-treated with Arsenic Trioxide] results in increased expression of CDKN1B protein; [NVP-BKM120 co-treated with Arsenic Trioxide] results in increased expression of CDKN1B mRNA; Arsenic Trioxide results in increased expression of and results in increased localization of CDKN1B protein; salvin promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1B protein]PMID:20698225 PMID:23239002 PMID:27430728 PMID:29574283 PMID:31539632 PMID:36352148
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