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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631365
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nampt
Name: nicotinamide phosphoribosyltransferase
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Namptdecreases expressionISONAMPT (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of NAMPT mRNA; Arsenic Trioxide results in decreased expression of NAMPT proteinPMID:28501332
Namptmultiple interactionsISONAMPT (Homo sapiens)6480464CTDArsenic Trioxide promotes the reaction [N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide results in decreased expression of NAMPT mRNA]; N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide promotes the reaction [Arsenic Trioxide results in decreased expression of NAMPT mRNA]PMID:28501332
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