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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3610
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rxra
Name: retinoid X receptor alpha
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rxradecreases expressionISORxra (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of RXRA proteinPMID:15916724
Rxraincreases expressionISORXRA (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of RXRA mRNAPMID:19769630
Rxraincreases phosphorylationISORxra (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of RXRA proteinPMID:15688020
Rxraincreases phosphorylationISORXRA (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of RXRA proteinPMID:16184197
Rxramultiple interactionsISORxra (Mus musculus)6480464CTDArsenic Trioxide inhibits the reaction [RXRA protein binds to PPARG protein]PMID:15916724
Rxramultiple interactionsISORXRA (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of RXRA protein]PMID:16184197
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