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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3439
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs1decreases expressionISOPTGS1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of PTGS1 mRNAPMID:26705709
Ptgs1multiple interactionsISOPTGS1 (Homo sapiens)6480464CTDArsenic Trioxide inhibits the reaction [Tretinoin results in increased expression of PTGS1 protein]PMID:18354491
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