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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3343
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plau
Name: plasminogen activator, urokinase
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plaudecreases expressionISOPLAU (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of PLAU mRNAPMID:15962302 PMID:21969006 PMID:23851143 PMID:27039805
Plauincreases expressionISOPLAU (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of PLAU mRNAPMID:20458559
Plaumultiple interactionsISOPLAU (Homo sapiens)6480464CTD[Silybin co-treated with Arsenic Trioxide] results in decreased expression of PLAU mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased secretion of PLAU protein]; Arsenic Trioxide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of PLAU protein]; Arsenic Trioxide promotes the reaction [Silybin results in decreased expression of PLAU mRNA]; Arsenic Trioxide results in decreased expression of and results in decreased secretion of PLAU protein; GH1 protein promotes the reaction [Arsenic Trioxide results in decreased expression of PLAU mRNA]; Silybin promotes the reaction [Arsenic Trioxide results in decreased expression of PLAU mRNA]PMID:15962302 PMID:21969006 PMID:23851143
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