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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc1
Name: ATP binding cassette subfamily C member 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc1decreases expressionISOABCC1 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of ABCC1 proteinPMID:19100828 PMID:31355259
Abcc1decreases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in decreased susceptibility to Arsenic TrioxidePMID:11331074 PMID:20707922 PMID:21783896
Abcc1increases expressionISOABCC1 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ABCC1 mRNA; Arsenic Trioxide results in increased expression of ABCC1 proteinPMID:27736728 PMID:29274627
Abcc1increases response to substanceISOABCC1 (Homo sapiens)6480464CTDABCC1 gene mutant form results in increased susceptibility to Arsenic TrioxidePMID:30815697
Abcc1increases secretionISOABCC1 (Homo sapiens)6480464CTDABCC1 protein results in increased secretion of Arsenic TrioxidePMID:12018890
Abcc1increases transportISOAbcc1 (Mus musculus)6480464CTDABCC1 protein results in increased transport of Arsenic TrioxidePMID:22699396
Abcc1multiple interactionsISOABCC1 (Homo sapiens)6480464CTD[verlukast results in decreased activity of ABCC1 protein] which results in increased susceptibility to Arsenic Trioxide; ABCC1 protein results in decreased uptake of and results in decreased susceptibility to Arsenic Trioxide; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Arsenic Trioxide]; Proanthocyanidins inhibits the reaction [Arsenic Trioxide results in decreased expression of ABCC1 protein]; verlukast inhibits the reaction [ABCC1 protein results in decreased susceptibility to Arsenic Trioxide]; verlukast inhibits the reaction [ABCC1 protein results in decreased uptake of and results in decreased susceptibility to Arsenic Trioxide]PMID:11331074 PMID:12018890 PMID:18633430 PMID:23052202 PMID:31355259
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