An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID:
MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Arsenic Trioxide results in decreased expression of PML mRNA mutant form; Arsenic Trioxide results in decreased expression of PML protein; Arsenic Trioxide results in decreased expression of PML protein mutant form
PML gene mutant form results in decreased susceptibility to Arsenic Trioxide; PML protein mutant form results in decreased susceptibility to Arsenic Trioxide; PML protein results in decreased susceptibility to Arsenic Trioxide
Arsenic Trioxide results in increased ubiquitination of PML protein; Arsenic Trioxide results in increased ubiquitination of PML protein alternative form
[[Arsenic Trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]] which results in increased degradation of PML protein alternative form; [[Arsenic Trioxide results in increased sumoylation of PML protein] promotes the reaction [PML protein binds to RNF4 protein]] which results in increased degradation of PML protein; [Arsenic Trioxide affects the reaction [SUMO2 protein binds to PML protein]] promotes the reaction [SUMO1 protein binds to PML protein]; [Arsenic Trioxide affects the reaction [SUMO2 protein binds to PML protein]] which results in increased ubiquitination of PML protein; [Arsenic Trioxide co-treated with PML protein] results in decreased expression of BCL2; [Arsenic Trioxide co-treated with PML protein] results in increased expression of TP53; [Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]] which results in increased ubiquitination of PML protein; [Arsenic Trioxide promotes the reaction [UBE2I protein binds to PML protein]] which results in increased sumoylation of PML protein; [Arsenic Trioxide results in increased sumoylation of PML protein alternative form] promotes the reaction [PML protein alternative form binds to RNF4 protein]; [Arsenic Trioxide results in increased sumoylation of PML protein] promotes the reaction [PML protein binds to RNF4 protein]; [monomethylarsonous acid co-treated with dimethylarsinous acid co-treated with Arsenic Trioxide] results in increased degradation of PML protein; [Tretinoin co-treated with Arsenic Trioxide] results in decreased expression of PML mRNA alternative form; [Tretinoin co-treated with Arsenic Trioxide] results in increased degradation of PML protein mutant form; [Vorinostat co-treated with Arsenic Trioxide] results in decreased expression of PML protein mutant form; ALDH3A1 protein inhibits the reaction [PML mutant form results in increased susceptibility to Arsenic Trioxide]; Arsenic Trioxide affects the localization of and results in decreased expression of PML protein; Arsenic Trioxide affects the reaction [PML protein modified form binds to DAXX protein]; Arsenic Trioxide affects the reaction [SUMO2 protein binds to PML protein]; Arsenic Trioxide affects the sumoylation of and results in increased ubiquitination of and results in increased cleavage of PML protein; Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to PML protein]; Arsenic Trioxide inhibits the reaction [p-aminophenylarsine oxide binds to PML protein]; Arsenic Trioxide promotes the reaction [PML protein binds to PML protein]; Arsenic Trioxide promotes the reaction [puerarin results in decreased expression of PML mRNA alternative form]; Arsenic Trioxide promotes the reaction [RNF4 protein binds to and results in increased degradation of PML protein modified form]; Arsenic Trioxide promotes the reaction [RNF4 protein results in increased degradation of PML protein alternative form]; Arsenic Trioxide promotes the reaction [RNF4 protein results in increased degradation of PML protein]; Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]; Arsenic Trioxide promotes the reaction [SUMO2 protein binds to PML protein]; Arsenic Trioxide promotes the reaction [tetraarsenic tetrasulfide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]; Arsenic Trioxide promotes the reaction [UBE2I protein binds to PML protein]; Arsenic Trioxide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]; Arsenic Trioxide results in increased expression of and results in increased sumoylation of PML protein; Arsenic Trioxide results in increased localization of [CASP8AP2 protein co-treated with PML protein]; Arsenic Trioxide results in increased localization of and results in increased degradation of PML protein; Arsenic Trioxide results in increased phosphorylation of and results in increased sumoylation of PML protein; Arsenic Trioxide results in increased sumoylation of and results in increased localization of PML protein; Arsenic Trioxide results in increased ubiquitination of and results in increased degradation of PML protein; cobaltous chloride promotes the reaction [Arsenic Trioxide results in increased degradation of PML protein mutant form]; Cycloheximide inhibits the reaction [Arsenic Trioxide results in increased degradation of PML protein]; Fenofibrate promotes the reaction [Arsenic Trioxide results in decreased expression of PML protein mutant form]; PIAS1 protein promotes the reaction [Arsenic Trioxide results in increased degradation of PML protein]; PML gene mutant form results in decreased susceptibility to [Arsenic Trioxide co-treated with Tretinoin]; PML protein affects the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; PML protein affects the reaction [Arsenic Trioxide results in increased expression of SUMO1 protein]; PML protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 protein]; RNF4 protein promotes the reaction [Arsenic Trioxide results in increased degradation of PML protein]; RNF4 protein promotes the reaction [Arsenic Trioxide results in increased ubiquitination of PML protein]; SENP1 protein promotes the reaction [Arsenic Trioxide affects the reaction [SUMO2 protein binds to PML protein]]; SENP1 protein promotes the reaction [Arsenic Trioxide affects the sumoylation of and results in increased ubiquitination of PML protein]; SENP1 protein promotes the reaction [Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]]; SUMO1 protein promotes the reaction [Arsenic Trioxide results in increased ubiquitination of PML protein]; SUMO2 protein mutant form inhibits the reaction [Arsenic Trioxide affects the reaction [SUMO2 protein binds to PML protein]]; SUMO2 protein mutant form inhibits the reaction [Arsenic Trioxide promotes the reaction [SUMO1 protein binds to PML protein]]; SUMO2 protein mutant form inhibits the reaction [Arsenic Trioxide results in increased ubiquitination of PML protein]; tetraarsenic tetrasulfide promotes the reaction [Arsenic Trioxide results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]; UBE2I protein affects the reaction [Arsenic Trioxide results in increased expression of and results in increased sumoylation of PML protein]
Arsenic Trioxide inhibits the reaction [Bleomycin results in increased expression of PML protein]; Arsenic Trioxide results in increased sumoylation of and results in increased localization of and results in increased degradation of [PML protein mutant form binds to PML protein mutant form]
