RGD Gene Chemical Interaction Report

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Keyword

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	2543
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Egfr
Name:	epidermal growth factor receptor

Acc ID:	CHEBI:49668
Term:	gefitinib
Definition:	A quinazoline that has formula C22H24ClFN4O3.
CasRN:	184475-35-2
Chemical ID:	MESH:C419708

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases response to substance	ISO	RGD:69152	6480464	CTD	EGFR gene mutant form results in decreased susceptibility to gefitinib	PMID:16740687
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR gene mutant form affects the susceptibility to gefitinib	PMID:18271929
increases response to substance	ISO	RGD:69152	6480464	CTD	EGFR gene mutant form results in increased susceptibility to gefitinib	PMID:16115929
increases response to substance	ISO	RGD:69152	6480464	CTD	EGFR gene polymorphism results in increased susceptibility to gefitinib	PMID:18625569
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein affects the susceptibility to gefitinib	PMID:20846305 PMID:18771084 PMID:16243822 PMID:15976335
decreases response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein mutant form results in decreased susceptibility to gefitinib	PMID:17290066
increases response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein mutant form results in increased susceptibility to gefitinib	PMID:17270025 PMID:16824645
multiple interactions	ISO	RGD:69152	6480464	CTD	[gefitinib co-treated with oxaliplatin] results in decreased phosphorylation of EGFR protein	PMID:13680161
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]	PMID:18927496 PMID:19318490 PMID:16243822
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein] gefitinib results in decreased activity of [EGFR protein binds to EGFR protein] gefitinib results in decreased activity of [EGFR protein binds to ERBB2 protein]	PMID:17898861
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [EGF results in increased phosphorylation of and results in increased activity of EGFR protein] gefitinib inhibits the reaction [EGF results in increased phosphorylation of EGFR protein] gefitinib promotes the reaction [EGF protein binds to EGFR protein] gefitinib promotes the reaction [EGFR protein binds to EGFR protein] [gefitinib promotes the reaction [EGFR protein binds to EGFR protein]] which results in decreased activity of EGFR protein	PMID:21787763
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [gemcitabine results in increased phosphorylation of and results in increased degradation of EGFR protein]	PMID:17146438
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [irinotecan metabolite results in increased phosphorylation of and results in increased activity of EGFR protein] gefitinib inhibits the reaction [irinotecan results in increased phosphorylation of and results in increased activity of EGFR protein]	PMID:15723263
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib promotes the reaction [IGF1R protein binds to EGFR protein]	PMID:17473213
decreases activity	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased activity of EGFR protein	PMID:17938326 PMID:20549698
multiple interactions	ISO	RGD:69152	6480464	CTD	[[gefitinib results in decreased activity of EGFR protein] which affects the localization of ABCG2 protein] which results in decreased export of Doxorubicin	PMID:17938326
decreases phosphorylation	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased phosphorylation of EGFR protein	PMID:14679152 PMID:13680161 PMID:17236550 PMID:17145836 PMID:17473213
decreases expression	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased expression of EGFR protein modified form	PMID:19288272
multiple interactions	ISO	RGD:10511	6480464	CTD	gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]	PMID:15841081
multiple interactions	ISO	RGD:69152	6480464	CTD	[ITGB1 protein results in increased activity of EGFR protein] which results in decreased susceptibility to gefitinib	PMID:21478906
decreases expression	EXP		6480464	CTD	gefitinib results in decreased expression of EGFR protein modified form	PMID:15660382
decreases phosphorylation	EXP		6480464	CTD	gefitinib results in decreased phosphorylation of EGFR protein	PMID:18375820
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein affects the susceptibility to gefitinib	PMID:20846305 PMID:15976335 PMID:16243822 PMID:18771084
increases response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein mutant form results in increased susceptibility to gefitinib	PMID:16824645 PMID:17270025
decreases activity	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased activity of EGFR protein	PMID:20549698 PMID:17938326
decreases phosphorylation	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased phosphorylation of EGFR protein	PMID:17236550 PMID:17473213 PMID:14679152 PMID:17145836 PMID:13680161
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein affects the susceptibility to gefitinib	PMID:20846305 PMID:18771084 PMID:15976335 PMID:16243822
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]	PMID:16243822 PMID:18927496 PMID:19318490
decreases phosphorylation	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased phosphorylation of EGFR protein	PMID:17236550 PMID:13680161 PMID:17473213 PMID:17145836 PMID:14679152
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein affects the susceptibility to gefitinib	PMID:16243822 PMID:20846305 PMID:18771084 PMID:15976335
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]	PMID:16243822 PMID:19318490 PMID:18927496
decreases phosphorylation	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased phosphorylation of EGFR protein	PMID:17473213 PMID:17145836 PMID:13680161 PMID:17236550 PMID:14679152
decreases phosphorylation	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased phosphorylation of EGFR protein	PMID:17236550 PMID:13680161 PMID:14679152 PMID:17145836 PMID:17473213
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein affects the susceptibility to gefitinib	PMID:15976335 PMID:20846305 PMID:16243822 PMID:18771084
multiple interactions	ISO	RGD:69152	6480464	CTD	gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]	PMID:18927496 PMID:16243822 PMID:19318490
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein affects the susceptibility to gefitinib	PMID:18771084 PMID:15976335 PMID:16243822 PMID:20846305
affects response to substance	ISO	RGD:69152	6480464	CTD	EGFR protein affects the susceptibility to gefitinib	PMID:15976335 PMID:16243822 PMID:18771084 PMID:20846305
decreases phosphorylation	ISO	RGD:69152	6480464	CTD	gefitinib results in decreased phosphorylation of EGFR protein	PMID:13680161 PMID:14679152 PMID:17145836 PMID:17236550 PMID:17473213
multiple interactions	ISO	RGD:10511	6480464	CTD	[gefitinib results in decreased activity of EGFR protein] which results in increased susceptibility to naphthalene gefitinib results in decreased phosphorylation of and results in decreased activity of EGFR protein	PMID:20935109

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