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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:49662
Term: indometacin
Definition: A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chemical ID: MESH:D007213
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2decreases activityEXP 6480464CTDIndomethacin results in decreased activity of ABCC2 proteinPMID:16026004
Abcc2decreases expressionEXP 6480464CTDIndomethacin results in decreased expression of ABCC2 mRNA; Indomethacin results in decreased expression of ABCC2 proteinPMID:17329856
Abcc2decreases activityISOABCC2 (Homo sapiens)6480464CTDIndomethacin results in decreased activity of ABCC2 proteinPMID:22646477
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTDIndomethacin inhibits the reaction [5-methoxypsoralen results in decreased activity of ABCC2 protein]; Indomethacin inhibits the reaction [[5-methoxypsoralen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [[Methoxsalen results in decreased activity of ABCC2 protein] which results in decreased export of and results in increased abundance of Daunorubicin]; Indomethacin inhibits the reaction [ABCC2 protein affects the export of 5-carboxyfluorescein diacetate]; Indomethacin inhibits the reaction [Methoxsalen results in decreased activity of ABCC2 protein]; Indomethacin promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]PMID:12702717 PMID:12704183 PMID:16636798 PMID:29079042
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