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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583621 Species: Rattus norvegicus RGD Object: Gene Symbol: Tcf7l2 Name: transcription factor 7-like 2 (T-cell specific, HMG-box)

Acc ID: CHEBI:49662 Term: indomethacin Definition: An indole-3-acetic acid that has formula C19H16ClNO4. CasRN: 53-86-1 Chemical ID: MESH:D007213

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1317786	6480464	CTD	Indomethacin inhibits the reaction [[CTNNB1 protein binds to TCF7L2 protein] which binds to CCND1 promoter]	PMID:11756231