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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10310
Species: Mus musculus
RGD Object: Gene
Symbol: Cd44
Name: CD44 antigen
Acc ID: CHEBI:49603
Term: lapatinib
Definition: A furan that has formula C29H26ClFN4O4S.
Chemical ID: MESH:C490728
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd44multiple interactionsISOCD44 (Homo sapiens)6480464CTD[Genistein co-treated with Lapatinib] inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; [Lapatinib results in decreased susceptibility to Lapatinib] which results in increased expression of CD44 protein; Lapatinib inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; Lapatinib inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]]PMID:26643609 PMID:33396024
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