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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61855
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gabra1
Name: gamma-aminobutyric acid type A receptor subunit alpha 1
Acc ID: CHEBI:49575
Term: diazepam
Definition: A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a methyl group at position 1 and a phenyl group at position 5.
Chemical ID: MESH:D003975
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabra1affects bindingEXP 728715RGDDiazepam binds to Gabra1 protein 
Gabra1decreases expressionEXP 6480464CTDDiazepam results in decreased expression of GABRA1 mRNAPMID:11804615 PMID:15802192
Gabra1increases activityEXP 6480464CTDDiazepam results in increased activity of GABRA1 proteinPMID:15613639
Gabra1multiple interactionsEXP 6480464CTDDiazepam promotes the reaction [Ethanol deficiency results in decreased expression of GABRA1 mRNA]PMID:14684873
Gabra1affects activityISOGABRA1 (Homo sapiens)6480464CTDDiazepam affects the activity of GABRA1 proteinPMID:15864560
Gabra1multiple interactionsISOGabra1 (Mus musculus)6480464CTDDiazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein]]PMID:1712603
Gabra1multiple interactionsISOGABRA1 (Homo sapiens)6480464CTDDiazepam promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Diazepam results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]PMID:26344803 PMID:29038840
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