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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311472 Species: Rattus norvegicus RGD Object: Gene Symbol: Spry2 Name: sprouty homolog 2 (Drosophila)

Acc ID: CHEBI:49375 Term: dasatinib (anhydrous) Definition: An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN). CasRN: 302962-49-8 Chemical ID: MESH:C488369

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:1322949	6480464	CTD	dasatinib results in decreased expression of SPRY2 mRNA	PMID:20579391