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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731438 Species: Homo sapiens RGD Object: Gene Symbol: MYC Name: v-myc myelocytomatosis viral oncogene homolog (avian)

Acc ID: CHEBI:4911 Term: etoposide Definition: A beta-D-glucoside that has formula C29H32O13. CasRN: 33419-42-0 Chemical ID: MESH:D005047

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	EXP		6480464	CTD	Etoposide results in decreased expression of MYC mRNA	PMID:21527772
multiple interactions	EXP		6480464	CTD	MYC protein promotes the reaction [Etoposide results in increased cleavage of CASP9 protein]	PMID:21324178
increases response to substance	EXP		6480464	CTD	MYC protein results in increased susceptibility to Etoposide	PMID:21324178