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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70486
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk2
Name: cyclin dependent kinase 2
Acc ID: CHEBI:4911
Term: etoposide
Definition: A furonaphthodioxole that has formula C29H32O13.
Chemical ID: MESH:D005047
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk2affects response to substanceISOCDK2 (Homo sapiens)6480464CTDCDK2 protein affects the susceptibility to EtoposidePMID:16217747
Cdk2increases expressionISOCDK2 (Homo sapiens)6480464CTDEtoposide results in increased expression of CDK2 proteinPMID:16417649
Cdk2multiple interactionsISOCDK2 (Homo sapiens)6480464CTDBRCA1 protein mutant form inhibits the reaction [Etoposide results in increased expression of CDK2 protein]; CDK2 affects the reaction [Etoposide results in increased phosphorylation of TPI1 protein]PMID:16417649 PMID:20149834
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