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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732061 Species: Homo sapiens RGD Object: Gene Symbol: CDK4 Name: cyclin-dependent kinase 4

Acc ID: CHEBI:4903 Term: 17alpha-ethynylestradiol Definition: A 17-hydroxy steroid that has formula C20H24O2. CasRN: 57-63-6 Chemical ID: MESH:D004997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO		6480464	CTD	Ethinyl Estradiol results in decreased expression of CDK4 mRNA	PMID:16140622 PMID:17108234 PMID:12655037
increases expression	ISO		6480464	CTD	Ethinyl Estradiol results in increased expression of CDK4 mRNA	PMID:16174780
decreases expression	ISO	RGD:621120	6480464	CTD	Ethinyl Estradiol results in decreased expression of CDK4 mRNA	PMID:17108234 PMID:16140622 PMID:12655037
increases expression	ISO	RGD:621120	6480464	CTD	Ethinyl Estradiol results in increased expression of CDK4 mRNA	PMID:16174780
decreases expression	ISO	RGD:621120	6480464	CTD	Ethinyl Estradiol results in decreased expression of CDK4 mRNA	PMID:17108234 PMID:12655037 PMID:16140622
decreases expression	ISO	RGD:621120	6480464	CTD	Ethinyl Estradiol results in decreased expression of CDK4 mRNA	PMID:16140622 PMID:17108234 PMID:12655037
decreases expression	ISO		6480464	CTD	Ethinyl Estradiol results in decreased expression of CDK4 mRNA	PMID:12655037 PMID:16140622 PMID:17108234
decreases expression	ISO		6480464	CTD	Ethinyl Estradiol results in decreased expression of CDK4 mRNA	PMID:17108234 PMID:16140622 PMID:12655037
decreases expression	ISO	RGD:621120	6480464	CTD	Ethinyl Estradiol results in decreased expression of CDK4 mRNA	PMID:12655037 PMID:16140622 PMID:17108234