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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730944 Species: Homo sapiens RGD Object: Gene Symbol: ABCB11 Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11

Acc ID: CHEBI:4903 Term: 17alpha-ethynylestradiol Definition: A 17-hydroxy steroid that has formula C20H24O2. CasRN: 57-63-6 Chemical ID: MESH:D004997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases activity	EXP		6480464	CTD	Ethinyl Estradiol results in decreased activity of ABCB11 protein	PMID:20829430
multiple interactions	ISO	RGD:730945	6480464	CTD	ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]	PMID:16606610
decreases expression	ISO	RGD:730945	6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCB11 mRNA	PMID:16606610
increases expression	ISO	RGD:730945	6480464	CTD	Ethinyl Estradiol results in increased expression of ABCB11 mRNA	PMID:17942748
affects expression	ISO	RGD:730945	6480464	CTD	Ethinyl Estradiol affects the expression of ABCB11 mRNA	PMID:17555576
multiple interactions	ISO	RGD:730945	6480464	CTD	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCB11 mRNA	PMID:17942748
decreases expression	ISO	RGD:619930	6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCB11 mRNA	PMID:17108234
decreases expression	ISO	RGD:619930	6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCB11 protein	PMID:12187295
multiple interactions	ISO	RGD:619930	6480464	CTD	Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]	PMID:12187295
decreases expression	ISO	RGD:619930	6480464	CTD	Ethinyl Estradiol results in decreased expression of ABCB11 protein	PMID:12187295 PMID:23146761