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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620298
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcg5
Name: ATP binding cassette subfamily G member 5
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg5affects expressionEXP 6480464CTDEthinyl Estradiol affects the expression of ABCG5 mRNAPMID:26865667
Abcg5decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of ABCG5 mRNAPMID:12963437 PMID:16105132 PMID:17351261 PMID:27765674
Abcg5multiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with Diosgenin] results in decreased expression of ABCG5 mRNA; [Ethinyl Estradiol results in decreased expression of ABCG5 mRNA] which results in decreased secretion of CholesterolPMID:12963437 PMID:16105132
Abcg5decreases expressionISOAbcg5 (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of ABCG5 mRNAPMID:16606610
Abcg5multiple interactionsISOAbcg5 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCG5 mRNA]PMID:16606610
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