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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619930
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases expressionEXP 15090804RGD17alpha-ethynylestradiol decreases expression of Abcb11 mRNA and protein in primary hepatocytes; decreases expression of mRNA in liver 
Abcb11decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of ABCB11 mRNA; Ethinyl Estradiol results in decreased expression of ABCB11 proteinPMID:12187295 PMID:17108234 PMID:23146761 PMID:27090119 PMID:27743861 PMID:27765674
Abcb11multiple interactionsEXP 6480464CTD4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]; GW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; NR1H4 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; PRKAA1 protein affects the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]PMID:12187295 PMID:27090119 PMID:27743861
Abcb11affects expressionISOAbcb11 (Mus musculus)6480464CTDEthinyl Estradiol affects the expression of ABCB11 mRNAPMID:17555576
Abcb11decreases activityISOABCB11 (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased activity of ABCB11 proteinPMID:20829430 PMID:23956101
Abcb11decreases expressionISOABCB11 (Homo sapiens)6480464CTDEthinyl Estradiol results in decreased expression of ABCB11 mRNAPMID:27743861
Abcb11decreases expressionISOAbcb11 (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of ABCB11 mRNA; Ethinyl Estradiol results in decreased expression of ABCB11 proteinPMID:16606610 PMID:26040663 PMID:27818225 PMID:34058177
Abcb11increases expressionISOAbcb11 (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of ABCB11 mRNAPMID:17942748 PMID:29112739
Abcb11multiple interactionsISOABCB11 (Homo sapiens)6480464CTD[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of ABCB11 mRNA; PRKACA protein affects the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; PRKACB protein affects the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]PMID:27344345 PMID:27743861
Abcb11multiple interactionsISOAbcb11 (Mus musculus)6480464CTD[Metformin co-treated with Ethinyl Estradiol] results in decreased expression of ABCB11 protein; [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ABCB11 mRNA; alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]; ESR1 gene mutant form inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCB11 mRNA]; ESR1 protein promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]; SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 protein]PMID:16606610 PMID:17942748 PMID:26040663 PMID:27818225 PMID:29112739 PMID:34058177
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