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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase mu 1
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1affects expressionEXP 6480464CTDEthinyl Estradiol affects the expression of GSTM1 mRNAPMID:17351261
Gstm1decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of GSTM1 mRNAPMID:15834898
Gstm1decreases expressionISOGstm1 (Mus musculus)6480464CTDEthinyl Estradiol results in decreased expression of GSTM5 mRNAPMID:14976129
Gstm1multiple interactionsISOGstm1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTM5 mRNAPMID:17942748
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