GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Abcc2 | decreases expression | EXP | | 15090804 | RGD | 17alpha-ethynylestradiol decreases expression of Abcc2 mRNA and protein in primary hepatocytes; decreases expression of mRNA in liver | | Abcc2 | affects localization | EXP | | 6480464 | CTD | Ethinyl Estradiol affects the localization of ABCC2 protein | PMID:17681005 | Abcc2 | decreases expression | EXP | | 6480464 | CTD | Ethinyl Estradiol results in decreased expression of ABCC2 mRNA; Ethinyl Estradiol results in decreased expression of ABCC2 protein | PMID:16554369 PMID:17686906 PMID:23146761 PMID:27090119 PMID:27743861 PMID:9462655 | Abcc2 | multiple interactions | EXP | | 6480464 | CTD | 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; [Ethinyl Estradiol co-treated with Diosgenin] results in increased expression of ABCC2 mRNA; [Ethinyl Estradiol co-treated with Spironolactone] results in increased expression of ABCC2 protein; Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; dorsomorphin inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 protein]; Ethinyl Estradiol results in decreased expression of and results in decreased localization of and results in decreased activity of ABCC2 protein; GW 4064 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; NR1H4 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; PRKAA1 protein inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased activity of ABCC2 protein]; Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA] | PMID:15843489 PMID:16105132 PMID:17686906 PMID:27090119 PMID:27743861 | Abcc2 | decreases expression | ISO | Abcc2 (Mus musculus) | 6480464 | CTD | Ethinyl Estradiol results in decreased expression of ABCC2 mRNA; Ethinyl Estradiol results in decreased expression of ABCC2 protein | PMID:26040663 PMID:27818225 | Abcc2 | decreases expression | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | Ethinyl Estradiol results in decreased expression of ABCC2 mRNA | PMID:27743861 | Abcc2 | increases uptake | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | ABCC2 protein results in increased uptake of Ethinyl Estradiol metabolite | PMID:14722317 | Abcc2 | multiple interactions | ISO | Abcc2 (Mus musculus) | 6480464 | CTD | alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; SRT1720 inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 protein] | PMID:26040663 PMID:27818225 | Abcc2 | multiple interactions | ISO | ABCC2 (Homo sapiens) | 6480464 | CTD | Ethinyl Estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]; Ethinyl Estradiol results in increased expression of and results in increased activity of ABCC2 protein; fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC2 protein]; PRKACA protein affects the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]; PRKACB protein affects the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA] | PMID:14722317 PMID:24685904 PMID:27743861 | | ||||||||||||||||||||||
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