• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10438 Species: Mus musculus RGD Object: Gene Symbol: Cyp1a2 Name: cytochrome P450, family 1, subfamily a, polypeptide 2

Acc ID: CHEBI:4903 Term: 17alpha-ethynylestradiol Definition: A 17-hydroxy steroid that has formula C20H24O2. CasRN: 57-63-6 Chemical ID: MESH:D004997

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases hydroxylation	ISO	RGD:735711	6480464	CTD	CYP1A2 protein results in increased hydroxylation of Ethinyl Estradiol	PMID:15304426
multiple interactions	ISO	RGD:735711	6480464	CTD	[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein [[Ethinyl Estradiol co-treated with Gestodene] results in decreased activity of CYP1A2 protein] which results in decreased metabolism of tizanidine	PMID:16198659
multiple interactions	ISO	RGD:735711	6480464	CTD	[Ethinyl Estradiol co-treated with norgestimate] results in decreased activity of CYP1A2 protein	PMID:16291717
decreases activity	ISO	RGD:735711	6480464	CTD	Ethinyl Estradiol results in decreased activity of CYP1A2 protein	PMID:18816299