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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708425
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Havcr1
Name: hepatitis A virus cellular receptor 1
Acc ID: CHEBI:49005
Term: deferasirox
Definition: A member of the class of triazoles, deferasirox is 1,2,4-triazole substituted by a 4-carboxyphenyl group at position 1 and by 2-hydroxyphenyl groups at positions 3 and 5. An orally active iron chelator, it is used to manage chronic iron overload in patients receiving long-term blood transfusions.
Chemical ID: MESH:C415250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Havcr1increases expressionEXP 6480464CTDdeferasirox results in increased expression of HAVCR1 proteinPMID:21439361
Havcr1increases expressionISOHavcr1 (Mus musculus)6480464CTDdeferasirox results in increased expression of HAVCR1 proteinPMID:21439361
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