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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1306661
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chuk
Name: component of inhibitor of nuclear factor kappa B kinase complex
Acc ID: CHEBI:49
Term: (+)-Tetrandrine
Definition: A bisbenzylisoquinoline alkaloid that has formula C38H42N2O6.
Chemical ID: MESH:C009438
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chukmultiple interactionsEXP 6480464CTDtetrandrine inhibits the reaction [IL1B protein results in increased phosphorylation of CHUK protein]; tetrandrine inhibits the reaction [TNF protein results in increased expression of CHUK protein]PMID:17201889 PMID:22001142
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