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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:48843
Term: disodium selenite
Definition: An inorganic sodium salt composed of sodium and selenite ions in a 2:1 ratio.
Chemical ID: MESH:D018038
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityEXP 6480464CTDSodium Selenite results in decreased activity of GSR proteinPMID:26697995
Gsrmultiple interactionsEXP 6480464CTDlupeol inhibits the reaction [Sodium Selenite results in decreased activity of GSR protein]; Sodium Selenite inhibits the reaction [Streptozocin results in decreased activity of GSR protein]PMID:22476978 PMID:26697995
Gsrincreases activityISOGsr (Mus musculus)6480464CTDSodium Selenite results in increased activity of GSR proteinPMID:20620206
Gsrincreases expressionISOGSR (Homo sapiens)6480464CTDSodium Selenite results in increased expression of GSR proteinPMID:21215776
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTDMethylmercury Compounds inhibits the reaction [Sodium Selenite results in increased activity of GSR protein]PMID:20620206
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