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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736925 Species: Homo sapiens RGD Object: Gene Symbol: GJA1 Name: gap junction protein, alpha 1, 43kDa

Acc ID: CHEBI:48607 Term: lithium chloride Definition: A metal chloride salt with a Li(+) counterion. CasRN: 7447-41-8 Chemical ID: MESH:D018021

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects localization	ISO	RGD:2690	6480464	CTD	Lithium Chloride affects the localization of GJA1 protein	PMID:21177194
multiple interactions	ISO	RGD:2690	6480464	CTD	[[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein] which affects the expression of GJA1 protein	PMID:18972237
increases expression	ISO	RGD:2690	6480464	CTD	Lithium Chloride results in increased expression of GJA1 protein	PMID:21177194