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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589755
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tyr
Name: tyrosinase
Acc ID: CHEBI:48400
Term: 3-(3,4-dihydroxyphenyl)propanoic acid
Definition: A monocarboxylic acid that is 3-phenylpropionic acid substituted by hydroxy groups at positions 3 and 4. Also known as dihydrocaffeic acid, it is a metabolite of caffeic acid and exhibits antioxidant activity.
Chemical ID: MESH:C000995
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tyrincreases oxidationISOTYR (Homo sapiens)6480464CTDTYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acidPMID:20685355
Tyrmultiple interactionsISOTYR (Homo sapiens)6480464CTD[TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of GlutathionePMID:20685355
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