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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:4806
Term: (-)-epigallocatechin 3-gallate
Definition: A gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin.
Chemical ID: MESH:C045651
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9affects activityISOCASP9 (Homo sapiens)6480464CTDepigallocatechin gallate affects the activity of CASP9 proteinPMID:23954321
Casp9increases activityISOCASP9 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased activity of CASP9 proteinPMID:15764647
Casp9increases cleavageISOCasp9 (Mus musculus)6480464CTDepigallocatechin gallate results in increased cleavage of CASP9 proteinPMID:34600025
Casp9increases cleavageISOCASP9 (Homo sapiens)6480464CTDepigallocatechin gallate analog results in increased cleavage of CASP9 proteinPMID:16115949
Casp9increases expressionISOCASP9 (Homo sapiens)6480464CTDepigallocatechin gallate results in increased expression of CASP9 proteinPMID:32512070
Casp9multiple interactionsISOCASP9 (Homo sapiens)6480464CTDepigallocatechin gallate inhibits the reaction [Nitroprusside binds to and results in increased activity of CASP9 protein]PMID:23665936
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