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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2350
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chrnb2
Name: cholinergic receptor nicotinic beta 2 subunit
Acc ID: CHEBI:4803
Term: epibatidine
Definition: An alkaloid that has formula C11H13ClN2.
Chemical ID: MESH:C082748
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chrnb2affects bindingEXP 2303194RGDEpibatidine binds to Chrnb2 protein 
Chrnb2affects bindingEXP 2303195RGDepibatidine binds to Chrnb4 protein in the rat retina 
Chrnb2affects bindingEXP 6480464CTDepibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]PMID:11124396 PMID:15615518 PMID:21942635
Chrnb2multiple interactionsEXP 6480464CTD2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to [CHRNA4 protein co-treated with CHRNB2 protein]; epibatidine binds to [NACHRA2 protein co-treated with CHRNB2 protein]; epibatidine binds to [NACHRALPHA1 protein co-treated with CHRNB2 protein]; epibatidine binds to [NACHRALPHA2 protein co-treated with CHRNB2 protein]; epibatidine binds to [NACHRALPHA3 protein co-treated with CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; epibatidine results in increased activity of [NACHRA1 protein co-treated with CHRNB2 protein]; LYNX1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; LYPD1 protein promotes the reaction [epibatidine binds to and results in increased activity of [CHRNA1 protein binds to CHRNB2 protein]]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA2 protein binds to CHRNB2 protein]]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]]PMID:10728888 PMID:16291090 PMID:16981889 PMID:19619141 PMID:21905669 PMID:21942635
Chrnb2affects bindingISOCHRNB2 (Homo sapiens)6480464CTDepibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]PMID:14645658
Chrnb2multiple interactionsISOCHRNB2 (Homo sapiens)6480464CTDAcetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; epibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; subecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]PMID:14645658 PMID:22060139
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