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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731401 Species: Mus musculus RGD Object: Gene Symbol: Adam17 Name: a disintegrin and metallopeptidase domain 17

Acc ID: CHEBI:47977 Term: 2-amino-2-deoxy-D-glucopyranose Definition: A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2. CasRN: 3416-24-8 Chemical ID: MESH:D005944

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:620404	6480464	CTD	Glucosamine inhibits the reaction [IL1B results in increased expression of ADAM17 mRNA] IL1B affects the reaction [Glucosamine results in increased expression of ADAM17 mRNA]	PMID:17109745
increases expression	ISO	RGD:620404	6480464	CTD	Glucosamine results in increased expression of ADAM17 mRNA	PMID:17109745