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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3031 Species: Rattus norvegicus RGD Object: Gene Symbol: Smad2 Name: SMAD family member 2

Acc ID: CHEBI:47977 Term: 2-amino-2-deoxy-D-glucopyranose Definition: A D-glucosamine whose structure comprises D-glucopyranose having an amino substituent at position 2. CasRN: 3416-24-8 Chemical ID: MESH:D005944

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1347299	6480464	CTD	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [Glucosamine analog results in increased phosphorylation of SMAD2 protein]	PMID:20458730
increases phosphorylation	ISO	RGD:1347299	6480464	CTD	Glucosamine analog results in increased phosphorylation of SMAD2 protein	PMID:20458730