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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3443
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptk2
Name: protein tyrosine kinase 2
Acc ID: CHEBI:4791
Term: endosulfan
Definition: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.
Chemical ID: MESH:D004726
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptk2decreases expressionISOPTK2 (Homo sapiens)6480464CTDEndosulfan results in decreased expression of PTK2 protein; Endosulfan results in decreased expression of PTK2 protein modified formPMID:28108160
Ptk2increases phosphorylationISOPTK2 (Homo sapiens)6480464CTDEndosulfan results in increased phosphorylation of PTK2 proteinPMID:22677888 PMID:32044604
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