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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:47898
Term: 4'-epidoxorubicin
Definition: An anthracycline that is the 4'-epi-isomer of doxorubicin.
Chemical ID: MESH:D015251
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDEpirubicin analog results in increased expression of ABCC2 mRNA; Epirubicin results in increased expression of ABCC2 mRNAPMID:22914566 PMID:23867903 PMID:26335193
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTD3',4',7-trihydroxyisoflavone inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]; formononetin inhibits the reaction [Epirubicin results in increased expression of ABCC2 mRNA]PMID:22914566 PMID:23867903
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