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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10531 Species: Mus musculus RGD Object: Gene Symbol: Epo Name: erythropoietin

Acc ID: CHEBI:4784 Term: enalapril Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration). CasRN: 75847-73-3 Chemical ID: MESH:D004656

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:735849	6480464	CTD	Enalapril results in decreased expression of EPO protein	PMID:2474097 PMID:9434678
decreases expression	ISO	RGD:735849	6480464	CTD	Enalapril results in decreased expression of EPO protein	PMID:9434678 PMID:2474097
multiple interactions	ISO	RGD:2559	6480464	CTD	Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]	PMID:19958114